The Curious Case of Benjamin Button is the name of a film directed by David Fincher released at the end of 2008, in which the main character, none other than the boy Benjamin Button, is the boy. This boy was born with the aging appearance of an old man, but over time, the older he gets, the younger he gets, which is completely contrary to the law of birth and death that any creature on Earth must follow. But perhaps few people know that the story of this movie is inspired by a completely real disease: Hutchinson-Gilford progeria syndrome.

But our protagonist today is Adalia Rose, from Texas, who was diagnosed with Hutchinson-Gilford progeria, a genetic condition also known as Benjamin Button disease, when she was just three months old. According to the report, the incidence of this disease is 1 in 4,000,000 babies worldwide. There are currently fewer than 500 cases of Progeria worldwide, and people with it usually have an average life expectancy of 13.

A 15-year-old girl with Benjamin Button disease in real life and with millions of followers on YouTube has died at the age of 15.
As she grew up, Adalia Rose also gradually became famous on social networks, attracting 2.91 million subscribers on YouTube and 379,000 Instagram followers. However, on January 13, her family had to inform followers that Adalia Rose had passed away the day before due to her condition at the age of 15.

Adalia Rose from Texas was diagnosed with Hutchinson-Gilford progeria, a genetic condition also known as Benjamin Button disease, when she was just three months old

She touched the hearts of millions of people and left a great mark on the hearts of all who knew her. She is no longer in pain and is dancing to the music she loves.

I really wish this wasn’t our reality but unfortunately it did. We would like to thank everyone who loved and supported her.

Thank you to all the doctors and nurses who have worked hard to keep her healthy over the years. Now the family would like to mourn this great loss privately.

Following the announcement, thousands of fans sent their condolences to Adalia’s family and prayed for her to rest in peace.

Adalia’s mother, Natalia Pallante, said doctors noticed something was wrong within the first 4 weeks of her life. Concerned about Adalia’s lack of “growth”, the single mother also discovered that “the skin on her belly is really too tight and looks strange”. Two months later, Natalia was devastated when she heard of her daughter’s life-changing diagnosis.

Around this time, Adalia began to lose her hair, small blood vessels appeared more, and her skin became much thinner. People with this disease are also at increased risk of dwarfism due to having an abnormal protein gene.

Along with a dizzying premature rate of aging, Adalia suffered from hair loss, body fat deficiency, varicose veins, an abnormally high voice, and severe joint stiffness.

After emerging as a social media phenomenon, Adalia began filming more makeup tutorials, covering songs and making funny dance videos. Adalia’s father, Ryan, said: “We have a superstar. Adalia is very popular on social media, and when we go out, there are a lot of people who recognize it. I don’t see anything wrong with describing Adalia as a diva, and I’m a huge fan of her. Whatever Adalia wants, I’ll do it for her.”
In December 2019, Jennifer Lopez designer Michael Costello gifted the YouTube star two special dresses for her 13th birthday.

One of the dresses is Princess Jasmine’s outfit from the movie Aladdin, while the other is pink, looking like something JLO would wear on the red carpet.

“My heart is broken. I was speechless and couldn’t stop crying. Adalia is very special to the people I’ve met. She’s an angel.” The designer gave words of love to Adalia Rose Williams and said that she changed his life a lot.

Adalia has attracted media attention due to her vivacious personality. When she first uploaded the clip to her Youtube channel, she received millions of views and followers. Many people say that Adalia gives them a great inspiration and makes them feel more in love with life. A lot of words of encouragement are sent to Adalia every day: “You are a wonderful girl, many people in the world are watching you every day, so have fun!”

Progeria syndrome is a very rare genetic syndrome in humans. Progeria was first described in 1886 by Jonathan Hutchinson and in 1897 by Hastings Gilford. According to the report, the incidence of this disease is 1 in 4,000,000 babies worldwide. The current medical literature has only recorded more than a few hundred cases of Progeria.

In 2003, the team of Dr. Nicolas Levy (Marseille) and researchers from the NIH (National Institutes of Health) discovered the cause of this syndrome. Progeria appears due to a mutation in the LMNA gene, the gene that produces Lamin A. A normal cell will divide a certain number of times so that a new series of cells can replace damaged or weakened cells. As people age, cells gradually lose that ability. Mutations in the Lamin A gene cause cells to divide faster. This is the cause of faster aging of cells. As a result, the appearance and function of many organs of the child become “premature aging”.

The incidence of Progeria syndrome does not differ between males and females, nor between races. These children have an average life expectancy of about 13 – 14 years. Most children do not live past adolescence. Only a few cases live past the age of 20.