Shameless online trolls went as far as saying 10-year-old Sophia Weaver’s life had no value because of her disability.

A 10-year-old girl whose facial difference made her the target of relentless online cruelty has passed away.

Sophia Weaver, who was born with differences affecting her face, feet and hands, passed away on Thursday after becoming seriously ill earlier in the week.

Her mum Natalie, from North Carolina and a passionate disability rights advocate, wrote on Twitter: “Our SweetSophia left this earth last night as she spent every day of her life, surrounded by love & adoration.

“Once we find the strength to move through this heartbreaking loss, we will continue helping others in her memory.”

Mum of disabled girl responds after troll used her image in a cruel online debate.

Alongside her physical differences, Sophia also lived with Type 1 diabetes and Rett syndrome, a rare neurological condition.

The little girl, who communicated through her eyes and small sounds, required around-the-clock care.

She became widely known after Natalie decided to speak publicly following a policy change by U.S. health provider Medicare.

But it wasn’t long before the family’s openness about Sophia’s condition attracted online trolls.

Among the many hurtful comments, one stood out after someone used a photo of Sophia to argue that babies with disabilities should not be born.

The comment, posted on Twitter, said: “It is okay to think that every child matters however a lot of them do not.

“Hence the amnio test…should be a mandatory test and if it proves negative and the woman does not want to terminate the pregnancy then all bills accrued after that is on her and the father.”

Despite the offensive post, Twitter initially declined to remove the comment.

Natalie continued to speak out, and Twitter later apologized to the Weaver family. The account responsible for the post was suspended.

Public figures, including former U.S. President Barack Obama, had previously praised Natalie’s work to improve access to health insurance for American families.

Natalie encouraged people to donate to sophias-voice.com to help other children living with chronic illnesses and disabilities.